Home 
Today's Top Picks 
Top Performers 
Watchlist 
My Robo Portfolios 
ETF Zone 
How It Works 
News - Chart
- Upturn Summary
- Highlights
- Valuation
Upturn AI Summary - About
Talphera Inc.(TLPH)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for TLPH
11/02/2026: TLPH (1-star) is currently NOT-A-BUY. Pass it for now.
Talphera Inc. is a small-cap specialty pharmaceutical company currently in the clinical development phase, having recently pivoted from its legacy pain management business. Its primary value proposition is the advancement of Niyad, a specialized drug candidate designed for use in hospital-based extracorporeal circuits. The company's main strength is its lean operational model and focused R&D strategy, while its primary risk is the high execution dependency on a single product's regulatory success. This stock is generally suited for aggressive, risk-tolerant investors who understand clinical-stage biopharmaceutical risks. Investors should closely monitor regulatory progress with the FDA, as it is the most critical catalyst for the company's long-term viability.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Weak fit | The company is at a speculative stage with high execution risk regarding regulatory approval. |
| Momentum investor | Mixed fit | This style is only relevant during high-volatility events like FDA decisions, which remain speculative. |
| Value investor | Weak fit | The lack of consistent earnings and high cash burn make it unsuitable for traditional value metrics. |
| Dividend investor | Weak fit | Talphera does not pay a dividend and focuses entirely on capital preservation and R&D. |
| Low-risk investor | Weak fit | The company's speculative nature and volatility profile are incompatible with low-risk investment goals. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | Clinical-stage stocks are prone to sharp price swings based on news and dilution. |
| Valuation risk | High | Company value is based on future product success rather than current earnings. |
| Competition risk (Hospital Pharmaceutical Suppliers) | High | Talphera faces established players with deep, entrenched hospital relationships. |
| Business quality | Low | The company is currently pre-revenue with high dependence on one clinical program. |
| Dividend income | Low / none | There is no income component to this investment. |
| Execution risk | High | Failure to achieve regulatory approval for Niyad would severely impact the company's viability. |
Price Behavior
Rolling Over
The price momentum is slowing down and beginning to turn downward.
Choppy
The stock has experienced frequent reversals and pronounced short-term price swings.
Analysis of Past Performance
Type Stock | Historic Profit 19.25% | Avg. Invested days 28 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  3.0 | Stock Returns Performance  2.0 |
| Profits based on simulation | Last Close 11/02/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 53.46M USD | Price to earnings Ratio - | 1Y Target Price 3.12 |
Price to earnings Ratio - | 1Y Target Price 3.12 | ||
Volume (30-day avg) 105.4K shares | Beta 0.68 | 52 Weeks Range 0.69 - 1.57 | Updated Date 11/01/2026 |
52 Weeks Range 0.69 - 1.57 | Updated Date 11/01/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.26 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Drug Development | Clinical and regulatory advancement of Niyad. | The company earns no money currently and relies on financing to develop its drug candidate. |
Valuation
Trailing PE - | Forward PE 1.02 | Enterprise Value 36.65M | Price to Sales(TTM) 53462.97 |
Enterprise Value 36.65M | Price to Sales(TTM) 53462.97 | ||
Enterprise Value to Revenue 36646.5 | Enterprise Value to EBITDA 0.11 | Shares Outstanding 51.91M | Shares Floating 25.23M |
Shares Outstanding 51.91M | Shares Floating 25.23M | ||
Percent Insiders 21.41 | Percent Institutions 46.23 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
Note: This website is maintained by Upturn Corporation, which is an investment adviser registered with the U.S. Securities and Exchange Commission. Such registration does not imply a certain level of skill or training. Investing in securities has risks. Past performance is no guarantee of future returns. No assurance is provided as to any particular investment return, and you may lose money using our services. You are strongly advised to consult appropriate counsel before making any investments in companies you learn about through our services. You should obtain appropriate legal, tax, investment, accounting, and other advice that takes into account your investment portfolio and overall financial situation. You are solely responsible for conducting due diligence on a potential investment. We do not affect trades for you. You will select your own broker through which to transact. Investments are not FDIC insured, they are not guaranteed, and they may lose value. Please see the Privacy Policy, Terms of Use, and Disclosure for more information.
All company names, trademarks, logos, and brands are the property of their respective owners and are used for identification and informational purposes only. Use of these names, trademarks, and logos does not imply endorsement by their respective owners.