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Tiziana Life Sciences Ltd (TLSA)


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Upturn Advisory Summary
10/21/2025: TLSA (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type Stock | Historic Profit -19.6% | Avg. Invested days 24 | Today’s Advisory WEAK BUY |
Upturn Star Rating ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Small-Cap Stock | Market Capitalization 186.96M USD | Price to earnings Ratio - | 1Y Target Price 3 |
Price to earnings Ratio - | 1Y Target Price 3 | ||
Volume (30-day avg) - | Beta 0.11 | 52 Weeks Range 0.63 - 1.91 | Updated Date 06/29/2025 |
52 Weeks Range 0.63 - 1.91 | Updated Date 06/29/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.11 |
Earnings Date
Report Date 2025-06-23 | When After Market | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -84.13% | Return on Equity (TTM) -250.49% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 183338371 | Price to Sales(TTM) - |
Enterprise Value 183338371 | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA -5.98 | Shares Outstanding 116848000 | Shares Floating 63394363 |
Shares Outstanding 116848000 | Shares Floating 63394363 | ||
Percent Insiders 43.06 | Percent Institutions 2.73 |
Upturn AI SWOT
Tiziana Life Sciences Ltd

Company Overview
History and Background
Tiziana Life Sciences Ltd is a biotechnology company focused on innovative therapeutics for oncology, inflammation, and infectious diseases. The company's founding date and initial milestones are not readily available in standard financial data platforms. Publicly traded, it has evolved through various clinical trials and partnerships.
Core Business Areas
- Oncology: Development of therapeutics for solid tumors, utilizing technologies like anti-IL-6 and anti-CD3 antibodies.
- Immunology: Research and development focused on modulating the immune system for treatment of inflammatory and autoimmune diseases.
- Infectious Diseases: Exploration of therapies to combat various infectious diseases.
Leadership and Structure
Details about Tiziana Life Sciences Ltd's specific leadership team and organizational structure are not readily accessible through standard data platforms. It would typically consist of a CEO, CFO, CMO, and a board of directors.
Top Products and Market Share
Key Offerings
- Foralumab (TZLS-401): An anti-CD3 monoclonal antibody in clinical development for autoimmune and inflammatory diseases, particularly Crohn's disease and multiple sclerosis. Market share data is unavailable due to clinical stage. Competitors include companies developing other anti-CD3 therapies and treatments for autoimmune disorders.
- Milciclib: A pan-CDK inhibitor in clinical development for hepatocellular carcinoma (HCC). Market share data is unavailable due to clinical stage. Competitors include companies developing other CDK inhibitors and treatments for HCC.
Market Dynamics
Industry Overview
The biotechnology industry is experiencing robust growth, driven by advancements in genomics, personalized medicine, and increasing demand for novel therapies. Focus areas include oncology, immunology, and infectious diseases, with significant competition and regulatory hurdles.
Positioning
Tiziana Life Sciences Ltd occupies a niche position within the biotechnology sector, focusing on innovative immunomodulation and targeted therapies. Its competitive advantage lies in its proprietary technology platforms and clinical development programs.
Total Addressable Market (TAM)
The TAM for its target indications (autoimmune diseases, cancer) is substantial, potentially reaching billions of dollars. Tiziana is positioning itself through clinical trials to capture a portion of this market, but it's early stage.
Upturn SWOT Analysis
Strengths
- Novel therapeutic candidates (Foralumab, Milciclib)
- Proprietary technology platforms
- Focus on unmet medical needs
- Experienced scientific team
Weaknesses
- Limited financial resources
- High risk of clinical trial failures
- Dependence on external funding
- Small market capitalization
Opportunities
- Successful clinical trial outcomes
- Strategic partnerships with larger pharmaceutical companies
- Expansion into new therapeutic areas
- Orphan drug designation for specific indications
Threats
- Competition from larger pharmaceutical companies
- Regulatory hurdles and delays
- Patent infringement lawsuits
- Economic downturn impacting investment in biotechnology
Competitors and Market Share
Key Competitors
- Not Available
Competitive Landscape
The company faces competition from established pharmaceutical companies and other biotechnology firms developing therapies for similar indications. Tiziana's advantages lie in its novel approaches but its smaller size can be a disadvantage.
Growth Trajectory and Initiatives
Historical Growth: Tiziana's historical growth is primarily driven by clinical trial progress and partnership agreements.
Future Projections: Future growth depends on clinical trial success and regulatory approvals. Analyst estimates are not readily available in standard platforms and require specialized financial data subscriptions.
Recent Initiatives: Recent initiatives include advancing Foralumab in clinical trials for Crohn's disease and multiple sclerosis, and Milciclib for HCC.
Summary
Tiziana Life Sciences is a biotechnology company focusing on novel immunomodulation and targeted therapies. Its strengths lie in its innovative technology platforms and focus on unmet medical needs, while weaknesses include limited financial resources and high clinical trial risks. Successful clinical trial outcomes and strategic partnerships are crucial for future growth. The company operates in a competitive landscape with both opportunities and threats.
Peer Comparison
Sources and Disclaimers
Data Sources:
- SEC Filings
- Company Website
- Press Releases
- Publicly Available Financial Data
- AI Analysis
Disclaimers:
This analysis is based on publicly available information and should not be considered financial advice. Investment in biotechnology companies is inherently risky. Market share data is unavailable and marked as zero.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Tiziana Life Sciences Ltd
Exchange NASDAQ | Headquaters - | ||
IPO Launch date 2000-03-24 | CEO & Executive Director Dr. Ivor R. Elrifi Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 9 | |
Full time employees 9 |
Tiziana Life Sciences Ltd, a biotechnology company, engages in the development of transformative therapies for neurodegenerative and lung diseases in the United States. The company's lead product candidate in immunology is Foralumab (TZLS-401), a human anti-CD3 monoclonal antibody (mAb) for use in the treatment of Crohn's, graft versus host, ulcerative colitis, multiple sclerosis, type-1 diabetes, inflammatory bowel, psoriasis, and rheumatoid arthritis diseases. It is also developing TZLS-501, a fully human mAb targeting the IL-6 receptor for use in the treatment of inflammatory and oncology indications. Tiziana Life Sciences Ltd was incorporated in 1998 and is headquartered in London, the United Kingdom.

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