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Upturn stock ratingUpturn stock rating
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Aptevo Therapeutics Inc (APVO)

Upturn stock ratingUpturn stock rating
$4.95
Last Close (24-hour delay)
upturn advisory
PASS
  • BUY Advisory
  • SELL Advisory (Profit)​
  • SELL Advisory (Loss)​
  • Profit
  • Loss
  • Pass (Skip investing)
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
  • YEAR
  • MONTH
  • WEEK

Upturn Advisory Summary

06/06/2025: APVO (1-star) is currently NOT-A-BUY. Pass it for now.

Upturn Star Rating

rating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

1 Analysts rated it

Very few follow this stock; limited insights, higher-risk early investing.

1 Year Target Price $420

1 Year Target Price $420

Analysts Price Target For last 52 week
$420Target price
Low$2.81
Current$4.95
high$485.37

Analysis of Past Performance

Type Stock
Historic Profit -54.71%
Avg. Invested days 11
Today’s Advisory PASS
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 1.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 06/06/2025

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 9.93M USD
Price to earnings Ratio -
1Y Target Price 420
Price to earnings Ratio -
1Y Target Price 420
Volume (30-day avg) 1
Beta 5.73
52 Weeks Range 2.81 - 485.37
Updated Date 06/30/2025
52 Weeks Range 2.81 - 485.37
Updated Date 06/30/2025
Dividends yield (FY) -
Basic EPS (TTM) -325.05

Analyzing Revenue: Products, Geography and Growth

Revenue by Products

Product revenue - Year on Year

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -
Operating Margin (TTM) -

Management Effectiveness

Return on Assets (TTM) -115.99%
Return on Equity (TTM) -1023.93%

Valuation

Trailing PE -
Forward PE 3.94
Enterprise Value 12213400
Price to Sales(TTM) 1.61
Enterprise Value 12213400
Price to Sales(TTM) 1.61
Enterprise Value to Revenue 0.12
Enterprise Value to EBITDA 0.39
Shares Outstanding 3224160
Shares Floating 374281
Shares Outstanding 3224160
Shares Floating 374281
Percent Insiders 9.95
Percent Institutions 0.43

Analyst Ratings

Rating 1
Target Price 420
Buy 1
Strong Buy -
Buy 1
Strong Buy -
Hold -
Sell -
Strong Sell -
Strong Sell -

ai summary icon Upturn AI SWOT

Aptevo Therapeutics Inc

stock logo

Company Overview

overview logo History and Background

Aptevo Therapeutics Inc. was founded in 2016 as a spin-off from Emergent BioSolutions. It focuses on developing novel immunotherapies for cancer and autoimmune diseases.

business area logo Core Business Areas

  • ADAPTIR Platform: Aptevo's core technology platform for generating novel biologic therapeutics.
  • Hematology: Developing and commercializing products for hematological malignancies.
  • Autoimmune Diseases: Researching and developing therapies for autoimmune and inflammatory conditions.

leadership logo Leadership and Structure

Marvin White is the President and CEO. The company has a typical biotech organizational structure with research, development, and commercial operations.

Top Products and Market Share

overview logo Key Offerings

  • Ruxience: A biosimilar to Rituxan (rituximab), used to treat certain blood cancers and autoimmune diseases. Aptevo receives royalties from sales of Ruxience by Pfizer. Competitors: Amgen (MVASI), Sandoz (Rixathon), Celltrion (Truxima).
  • Apexigen Collaboration: Aptevo provides services to Apexigen to advance APX005M, a novel CD40 antibody. The revenue from the collaboration is a key financial aspect for the company.

Market Dynamics

industry overview logo Industry Overview

The immunotherapy market is experiencing significant growth, driven by advancements in cancer treatment and autoimmune disease therapies. The market is competitive with many large and small biotech companies.

Positioning

Aptevo is a smaller player focused on leveraging its ADAPTIR platform to create differentiated immunotherapies and collaborations. They are focusing on Hematology and other related diseases

Total Addressable Market (TAM)

The TAM for immunotherapies is estimated to be in the hundreds of billions of dollars. Aptevo's positioning focuses on niche areas within this larger market, allowing them to compete by focusing on their innovative technology platform

Upturn SWOT Analysis

Strengths

  • ADAPTIR platform technology
  • Expertise in antibody engineering
  • Strategic collaborations
  • Focused on high-growth immunotherapy market

Weaknesses

  • Limited financial resources
  • Dependence on collaborations
  • Early-stage product pipeline
  • Small market capitalization

Opportunities

  • Expanding partnerships with larger pharmaceutical companies
  • Advancing pipeline candidates through clinical trials
  • Acquiring or licensing complementary technologies
  • Government grants and funding for research

Threats

  • Competition from larger pharmaceutical companies
  • Clinical trial failures
  • Regulatory hurdles
  • Intellectual property challenges
  • Economic downturn affecting investment in biotech

Competitors and Market Share

competitor logo Key Competitors

  • PFE
  • JNJ
  • MRK
  • BMY
  • ABBV

Competitive Landscape

Aptevo competes with larger pharmaceutical companies in the immunotherapy space, relying on its ADAPTIR platform to create novel therapies. They must continue to differentiate themselves from the larger firms through novel and innovative technology.

Growth Trajectory and Initiatives

Historical Growth: Historical growth has been dependent on milestones and revenues from collaborations.

Future Projections: Future growth depends on the successful development and commercialization of pipeline candidates and the securing of new partnerships.

Recent Initiatives: Focus on advancing core pipeline assets and seeking strategic partnerships.

Summary

Aptevo Therapeutics is a development-stage biotech company with an innovative technology platform but limited financial resources. Its success hinges on advancing its pipeline through clinical trials and securing strategic partnerships to create shareholder value. The company needs to be careful about cash burn. Their dependence on collaborations makes them vulnerable to market and partnership headwinds.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Company Website
  • SEC Filings
  • Analyst Reports

Disclaimers:

This analysis is for informational purposes only and should not be considered financial advice. Market data is subject to change.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Aptevo Therapeutics Inc

Exchange NASDAQ
Headquaters Seattle, WA, United States
IPO Launch date 2016-07-20
President, CEO & Director Mr. Marvin L. White
Sector Healthcare
Industry Biotechnology
Full time employees 37
Full time employees 37

Aptevo Therapeutics Inc., a clinical-stage research and development biotechnology company, focuses on developing immunotherapeutic candidates for the treatment of various forms of cancer in the United States. The company develops its products using ADAPTIR and ADAPTIR-FLEX platforms to generate monospecific, bispecific, and multi-specific antibody candidates capable of enhancing the human immune system against cancer cells. Its lead clinical blood cancer candidate is mipletamig that is in Phase 1b/2 clinical trial for the treatment of acute myelogenous leukemia. The company also develops ALG.APV-527, a novel investigational bispecific ADAPTIR candidate that is in Phase 1 clinical trial for the treatment of non-small cell lung cancer, head and neck, colorectal, pancreatic, breast, and other solid tumors; APVO603, a preclinical dual agonist bispecific ADAPTIR candidate to treat multiple solid tumors; APVO442, a preclinical bispecific candidate based on the ADAPTIR-FLEX platform technology for the treatment of multiple solid tumors; and APVO711, a preclinical dual mechanism bispecific ADAPTIR candidate to treat prostate cancer. It has a collaboration and option agreement with Alligator Bioscience AB to develop ALG.APV-527. Aptevo Therapeutics Inc. was incorporated in 2016 and is headquartered in Seattle, Washington.