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Upturn AI Summary - About
Aptevo Therapeutics Inc(APVO)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for APVO
10/19/2026: APVO (1-star) is currently NOT-A-BUY. Pass it for now.
Aptevo Therapeutics is a clinical-stage biotechnology company focused on developing innovative bispecific antibody candidates using its proprietary ADAPTIR platform to address unmet needs in oncology. The company's main strength lies in its specialized technology and a pipeline concentrated on promising cancer targets. Its primary investment story hinges on successful clinical trial outcomes and the potential for strategic partnerships to validate its assets. Key risks include the high probability of clinical failure, significant financial burn, and competition from better-resourced pharmaceutical firms. This stock is best suited for high-risk tolerance investors who focus on long-term clinical development and should monitor upcoming trial readouts closely.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Weak fit | The company is in an early clinical stage with high risk and lacks established commercial growth. |
| Momentum investor | Weak fit | The stock often lacks sustained upward momentum and is subject to binary clinical trial risks. |
| Value investor | Weak fit | The lack of earnings and cash flow makes traditional valuation metrics difficult to apply. |
| Dividend investor | Weak fit | Aptevo does not pay a dividend and focuses on cash preservation for R&D. |
| Low-risk investor | Weak fit | The high volatility and clinical-stage nature represent a high-risk profile. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | The stock is subject to significant price swings based on clinical news and market sentiment. |
| Valuation risk | High | Without commercial products, it is difficult to determine an intrinsic value based on earnings. |
| Competition risk (oncology therapeutics) | High | The company competes with much larger players who have greater resources to develop similar drugs. |
| Business quality | Medium | While the technology platform is specialized, the business lacks the stability of revenue-generating entities. |
| Dividend income | Low / none | Investors should not expect any income from this stock. |
| Execution risk | High | Success depends entirely on the complex and uncertain process of clinical trials and regulatory approval. |
Price Behavior
Steep Decline
The stock price has dropped sharply with strong downward pressure.
Extreme Price Shocks
The stock has experienced exceptionally large and disruptive price movements during the period.
Analysis of Past Performance
Type Stock | Historic Profit -29.35% | Avg. Invested days 3 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  1.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 10/19/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 2.93M USD | Price to earnings Ratio 0.02 | 1Y Target Price 25.5 |
Price to earnings Ratio 0.02 | 1Y Target Price 25.5 | ||
Volume (30-day avg) 59.0K shares | Beta 1.68 | 52 Weeks Range 1.37 - 28.98 | Updated Date 10/18/2026 |
52 Weeks Range 1.37 - 28.98 | Updated Date 10/18/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) 66.96 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Clinical Development Pipeline | Potential future revenue from the licensing or commercialization of bispecific antibody candidates like APVO442. | The company does not currently generate significant recurring revenue and relies on potential future drug successes. |
Analyzing Revenue: Products, Geography and Growth
Revenue by Products
Product revenue - Year on Year
Valuation
Trailing PE 0.02 | Forward PE 3.89 | Enterprise Value -2.17M | Price to Sales(TTM) 2.7 |
Enterprise Value -2.17M | Price to Sales(TTM) 2.7 | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.39 | Shares Outstanding 1.81M | Shares Floating 1.70M |
Shares Outstanding 1.81M | Shares Floating 1.70M | ||
Percent Insiders 4.15 | Percent Institutions 2.88 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
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