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Bluebird bio Inc (BLUE)

Upturn stock ratingUpturn stock rating
$4.97
Last Close (24-hour delay)
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PASS
  • BUY Advisory
  • SELL Advisory (Profit)​
  • SELL Advisory (Loss)​
  • Profit
  • Loss
  • Pass (Skip investing)
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
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  • ALL
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Upturn Advisory Summary

05/30/2025: BLUE (1-star) is currently NOT-A-BUY. Pass it for now.

Upturn Star Rating

ratingratingratingratingrating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

4 Analysts rated it

These Stocks/ETFs, based on Upturn Advisory, frequently surpass the market, reflecting reliable and trustworthy advice.

Year Target Price $8

Year Target Price $8

Analyst’s Price TargetsFor last 52 week
$8Target price
Low$3.2
Current$4.97
high$28.6

Analysis of Past Performance

Type Stock
Historic Profit -67.18%
Avg. Invested days 14
Today’s Advisory PASS
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 1.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 05/30/2025

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 48.67M USD
Price to earnings Ratio -
1Y Target Price 8
Price to earnings Ratio -
1Y Target Price 8
Volume (30-day avg) -
Beta 0.36
52 Weeks Range 3.20 - 28.60
Updated Date 06/29/2025
52 Weeks Range 3.20 - 28.60
Updated Date 06/29/2025
Dividends yield (FY) -
Basic EPS (TTM) -20.59

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -192.39%
Operating Margin (TTM) -55.56%

Management Effectiveness

Return on Assets (TTM) -28.37%
Return on Equity (TTM) -546.54%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 158068516
Price to Sales(TTM) 0.47
Enterprise Value 158068516
Price to Sales(TTM) 0.47
Enterprise Value to Revenue 1.52
Enterprise Value to EBITDA -1.5
Shares Outstanding 9792460
Shares Floating 9725967
Shares Outstanding 9792460
Shares Floating 9725967
Percent Insiders 0.71
Percent Institutions 39.68

Analyst Ratings

Rating 3.25
Target Price 8
Buy 1
Strong Buy -
Buy 1
Strong Buy -
Hold 3
Sell -
Strong Sell -
Strong Sell -

ai summary icon Upturn AI SWOT

Bluebird bio Inc

stock logo

Company Overview

overview logo History and Background

Bluebird bio, Inc. was founded in 1992. Initially focused on gene therapy for genetic diseases, it has evolved through various clinical and regulatory hurdles. It has focused on severe genetic diseases and cancer.

business area logo Core Business Areas

  • Severe Genetic Diseases: Bluebird bio develops gene therapies for severe genetic diseases, including sickle cell disease and beta-thalassemia. Focus is on one-time potentially curative gene therapies.
  • Oncology: Focusing on the development of gene therapies in oncology, with focus on hematologic malignancies.

leadership logo Leadership and Structure

Andrew Obenshain is the CEO. The company has a typical biotech structure with R&D, clinical development, manufacturing, and commercial operations departments.

Top Products and Market Share

overview logo Key Offerings

  • Zynteglo (betibeglogene autotemcel): A gene therapy approved for beta-thalassemia. Competitors include traditional blood transfusions and iron chelation therapies. Limited market share data available due to newness and pricing challenges. Novartis is a major competitor in gene therapy.
  • Skysona (elivaldogene autotemcel): A gene therapy approved for cerebral adrenoleukodystrophy (CALD). Competitors are allogeneic hematopoietic stem cell transplant (allo-HSCT). Limited market share data due to the rarity of the disease and treatment.
  • Lyfgenia (lovotibeglogene autotemcel): A gene therapy approved for sickle cell disease. Competitors include hydroxyurea and chronic blood transfusions.

Market Dynamics

industry overview logo Industry Overview

The gene therapy market is rapidly growing, driven by technological advancements and increasing investment. High costs and regulatory complexities remain significant challenges.

Positioning

Bluebird bio is positioned as a pioneer in gene therapy, but faces competition from larger pharmaceutical companies and other specialized biotech firms.

Total Addressable Market (TAM)

The overall gene therapy market is expected to reach billions of dollars. Bluebird bio's success is contingent on gaining significant share within its targeted disease areas, especially with Zynteglo, Skysona, and Lyfgenia.

Upturn SWOT Analysis

Strengths

  • Pioneering gene therapy platform
  • Approved gene therapies for rare diseases
  • Strong scientific expertise
  • Focus on severe genetic diseases with high unmet need

Weaknesses

  • High cost of therapies
  • Regulatory challenges
  • Manufacturing complexities
  • Limited commercial success to date
  • Cash burn rate

Opportunities

  • Expanding indications for existing therapies
  • Developing new gene therapies for other diseases
  • Strategic partnerships with larger pharmaceutical companies
  • Improved manufacturing processes to reduce costs

Threats

  • Competition from other gene therapy companies
  • Regulatory setbacks
  • Reimbursement challenges
  • Clinical trial failures
  • Safety concerns with gene therapies

Competitors and Market Share

competitor logo Key Competitors

  • CRSP
  • EDIT
  • NTLA
  • SRPT
  • BMY
  • NVS

Competitive Landscape

Bluebird bio has a first-mover advantage in some areas but faces strong competition from larger pharmaceutical companies and other gene therapy specialists. Its high prices pose a disadvantage.

Growth Trajectory and Initiatives

Historical Growth: Historical growth has been inconsistent due to clinical and regulatory challenges.

Future Projections: Future growth depends on successful commercialization of approved therapies, pipeline progress, and access to funding. Analyst estimates vary widely.

Recent Initiatives: Focus on commercializing approved therapies, cost reduction measures, and pipeline development.

Summary

Bluebird bio is a pioneering gene therapy company facing significant challenges in commercializing its expensive therapies. It has obtained key approvals for Zynteglo, Lyfgenia, and Skysona, but needs to overcome cost hurdles and competition to achieve sustainable growth. Financial stability and pipeline development remain crucial for its long-term success. The company must navigate a complex regulatory landscape while addressing reimbursement concerns to fully realize the potential of its gene therapy platform.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Company SEC Filings
  • Analyst Reports
  • Industry News
  • Company Website

Disclaimers:

This analysis is based on publicly available information and is for informational purposes only. It is not financial advice. Market share data is estimated and may not be precise. Please conduct your own due diligence before making investment decisions.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Bluebird bio Inc

Exchange NASDAQ
Headquaters Somerville, MA, United States
IPO Launch date 2013-06-19
President, CEO & Director Mr. Andrew Obenshain
Sector Healthcare
Industry Biotechnology
Full time employees 248
Full time employees 248

bluebird bio, Inc., a biotechnology company, researches, develops, and commercializes gene therapies for curative severe genetic diseases in the United States. The company's product candidates for severe genetic diseases include ZYNTEGLO (betibeglogene autotemcel) for the treatment of transfusion-dependent ß-thalassemia; LYFGENIA (lovotibeglogene autotemcel) for the treatment of sickle cell disease (SCD) and a history of vaso-occlusive events; and SKYSONA (elivaldogene autotemcel) to treat cerebral adrenoleukodystrophy. Its clinical development programs include HGB-205, HGB-206, and HGB-210 to evaluate the safety and efficacy of lovo-cel in the treatment of patients with SCD; and HGB-204, HGB-205, HGB-207, and HGB-212 to evaluate the safety and efficacy of beti-cel in the treatment of patients with ß-thalassemia. The company was formerly known as Genetix Pharmaceuticals, Inc., and changed its name to bluebird bio, Inc. in September 2010. bluebird bio, Inc. was incorporated in 1992 and is headquartered in Somerville, Massachusetts. As of May 29, 2025, bluebird bio, Inc. was taken private.