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Upturn AI Summary - About
Lyell Immunopharma Inc(LYEL)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for LYEL
11/10/2026: LYEL (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Lyell Immunopharma is a clinical-stage biotechnology company focused on overcoming the biological challenges of T-cell therapy in solid tumors. The company's core strength lies in its proprietary Gen-R and Epi-R platforms, which aim to enhance T-cell function and persistence. While the potential for transformative oncology treatments provides an attractive long-term growth narrative, the company remains pre-revenue and faces high risks related to clinical trial outcomes and intense competition from established pharmaceutical leaders. Investors should monitor clinical data readouts closely, as these are the primary catalysts for value creation. Given its risk profile, Lyell is best suited for growth-oriented investors with a high tolerance for volatility.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Mixed fit | The company offers high-risk, high-reward potential dependent on clinical data success rather than proven growth. |
| Momentum investor | Weak fit | Momentum is generally lacking; a positive signal would require definitive, successful clinical results. |
| Value investor | Weak fit | The company is in a capital-consuming pre-revenue stage, making traditional value metrics inapplicable. |
| Dividend investor | Weak fit | Lyell is a clinical-stage biotechnology company that does not pay dividends. |
| Low-risk investor | Weak fit | The inherent volatility of clinical-stage biotech poses high risks unsuitable for conservative investors. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | The stock is susceptible to large swings based on clinical data releases and sector sentiment. |
| Valuation risk | Medium / high | Valuation is speculative and heavily dependent on long-term clinical trial success. |
| Competition risk (Biotech) | High | Well-capitalized competitors could reach the market first or produce superior clinical outcomes. |
| Business quality | Medium | While the technology is innovative, the company has yet to establish a commercially viable product franchise. |
| Dividend income | Low / none | No dividend income is available for investors. |
| Execution risk | High | Successful execution of complex manufacturing and clinical trial protocols is essential to long-term survival. |
Price Behavior
Steep Decline
The stock price has dropped sharply with strong downward pressure.
Extreme Price Shocks
The stock has experienced exceptionally large and disruptive price movements during the period.
Analysis of Past Performance
Type Stock | Historic Profit -10.12% | Avg. Invested days 27 | Today’s Advisory Consider higher Upturn Star rating |
Upturn Advisory Rating  | Upturn Advisory Performance  2.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 11/10/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 379.11M USD | Price to earnings Ratio - | 1Y Target Price 38.38 |
Price to earnings Ratio - | 1Y Target Price 38.38 | ||
Volume (30-day avg) 215.9K shares | Beta -0.09 | 52 Weeks Range 7.20 - 45.00 | Updated Date 11/10/2026 |
52 Weeks Range 7.20 - 45.00 | Updated Date 11/10/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -12.61 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Cell Therapy R&D | Clinical trial development for oncology candidates like LYL797. | The company is currently spending money to invent medicines rather than earning money from sales. |
Analyzing Revenue: Products, Geography and Growth
Revenue by Products
Product revenue - Year on Year
Valuation
Trailing PE - | Forward PE - | Enterprise Value 221.32M | Price to Sales(TTM) 25273.96 |
Enterprise Value 221.32M | Price to Sales(TTM) 25273.96 | ||
Enterprise Value to Revenue 14754.75 | Enterprise Value to EBITDA 0.25 | Shares Outstanding 24.59M | Shares Floating 9.89M |
Shares Outstanding 24.59M | Shares Floating 9.89M | ||
Percent Insiders 28.63 | Percent Institutions 48.91 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
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