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Upturn AI Summary - About
MeiraGTx Holdings PLC(MGTX)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for MGTX
10/23/2026: MGTX (1-star) is currently NOT-A-BUY. Pass it for now.
MeiraGTx Holdings PLC is a clinical-stage biotechnology company focused on developing gene therapies for rare and inherited diseases. Its primary strength lies in a vertically integrated business model, combining proprietary manufacturing with an innovative 'on/off' switch technology called riboswitch. The main investment story centers on the potential of its pipeline to deliver curative treatments for conditions that currently lack options. However, as a pre-commercial firm, the company faces significant execution and financial risks, including the inherent uncertainty of clinical trials and the need for ongoing capital. This stock is best suited for risk-tolerant, long-term growth investors who monitor clinical trial developments and partnership milestones.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Mixed fit | The company offers potential for high growth if clinical trials succeed, but the speculative nature of the pipeline involves significant risk. |
| Momentum investor | Strong fit while signal remains positive | Momentum investors may find opportunities around major clinical data release catalysts. |
| Value investor | Weak fit | The company does not have consistent earnings or tangible cash flows required for a traditional value-based assessment. |
| Dividend investor | Weak fit | The company does not pay dividends and is in a growth-intensive, pre-profit stage. |
| Low-risk investor | Weak fit | The inherent volatility of clinical-stage biotech makes this stock unsuitable for low-risk portfolios. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | Clinical trial results can lead to drastic, sudden changes in share price. |
| Valuation risk | High | Valuations for pre-revenue companies are highly subjective and sensitive to market sentiment. |
| Competition risk (Biotech) | High | Better-funded competitors may bring superior or faster alternatives to market. |
| Business quality | Medium | The company possesses strong technical expertise but lacks a proven commercial track record. |
| Dividend income | Low / none | No capital return program exists for shareholders. |
| Execution risk | High | Success depends on complex scientific processes and navigating difficult regulatory landscapes. |
Price Behavior
Rolling Over
The price momentum is slowing down and beginning to turn downward.
Choppy
The stock has experienced frequent reversals and pronounced short-term price swings.
Analysis of Past Performance
Type Stock | Historic Profit -24.72% | Avg. Invested days 35 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  3.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 10/23/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 884.56M USD | Price to earnings Ratio 10.71 | 1Y Target Price 27.75 |
Price to earnings Ratio 10.71 | 1Y Target Price 27.75 | ||
Volume (30-day avg) 991.8K shares | Beta 1.35 | 52 Weeks Range 6.62 - 15.35 | Updated Date 10/23/2026 |
52 Weeks Range 6.62 - 15.35 | Updated Date 10/23/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) 0.86 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Collaboration and Licensing | Milestone payments and royalties from partnerships for proprietary gene therapy assets. | Revenue is currently episodic and tied to achieving specific research and clinical progress. |
Analyzing Revenue: Products, Geography and Growth
Revenue by Products
Product revenue - Year on Year
Valuation
Trailing PE 10.71 | Forward PE 64.1 | Enterprise Value 724.06M | Price to Sales(TTM) 2.23 |
Enterprise Value 724.06M | Price to Sales(TTM) 2.23 | ||
Enterprise Value to Revenue 19.1 | Enterprise Value to EBITDA -3.29 | Shares Outstanding 96.04M | Shares Floating 53.77M |
Shares Outstanding 96.04M | Shares Floating 53.77M | ||
Percent Insiders 16.27 | Percent Institutions 70.72 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
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