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Upturn AI Summary - About
Neurogene Inc(NGNE)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for NGNE
10/28/2026: NGNE (1-star) is currently NOT-A-BUY. Pass it for now.
Neurogene Inc is a clinical-stage biotechnology company that develops precision gene therapies for rare, severe neurological diseases. Its primary strength lies in its proprietary EXACT platform, which aims to improve the safety and efficacy of genetic medicines. The company's investment story hinges on the success of its lead programs, NGN-401 and NGN-101, which are currently progressing through clinical trials. Primary risks include the high probability of clinical failure, intense competition in the gene therapy space, and the need for ongoing capital to fund operations. This stock is best suited for growth-oriented investors with a high risk tolerance who are closely monitoring clinical trial data and regulatory updates.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Mixed fit | Neurogene offers high-growth potential linked to breakthrough gene therapy technology, but carries extreme binary risk. |
| Momentum investor | Mixed fit | This stock may see sharp price moves on clinical data, but fits best only during confirmed positive trend signals. |
| Value investor | Weak fit | As a pre-revenue biotech firm, traditional valuation metrics like P/E ratios are not applicable. |
| Dividend investor | Weak fit | The company does not pay dividends and is in an aggressive cash-spending phase. |
| Low-risk investor | Weak fit | The high volatility and clinical risk inherent in early-stage biotech make this unsuitable for risk-averse investors. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | Clinical-stage biotech stocks frequently experience massive swings based on regulatory or trial news. |
| Valuation risk | Medium / high | Valuation is speculative and heavily dependent on long-term, unproven clinical success. |
| Competition risk (gene therapy) | High | The sector is crowded with well-funded competitors racing to provide solutions for the same rare diseases. |
| Business quality | Medium | The company relies on a novel, proprietary technology platform that has not yet been validated by an approved product. |
| Dividend income | Low / none | There is no income generation for investors from this security. |
| Execution risk | High | Successful execution of complex clinical trials and the regulatory path to approval is difficult and uncertain. |
Price Behavior
Rolling Over
The price momentum is slowing down and beginning to turn downward.
Choppy
The stock has experienced frequent reversals and pronounced short-term price swings.
Analysis of Past Performance
Type Stock | Historic Profit -47.6% | Avg. Invested days 23 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  2.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 10/28/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 540.11M USD | Price to earnings Ratio - | 1Y Target Price 77.88 |
Price to earnings Ratio - | 1Y Target Price 77.88 | ||
Volume (30-day avg) 387.3K shares | Beta 2.09 | 52 Weeks Range 15.93 - 43.66 | Updated Date 10/28/2026 |
52 Weeks Range 15.93 - 43.66 | Updated Date 10/28/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -5.04 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Research and Development | Clinical trial development and intellectual property related to gene therapy platforms. | The company currently spends money to create products and has no commercial revenue yet. |
Analyzing Revenue: Products, Geography and Growth
Revenue by Products
Product revenue - Year on Year
Valuation
Trailing PE - | Forward PE - | Enterprise Value 254.43M | Price to Sales(TTM) 438.73 |
Enterprise Value 254.43M | Price to Sales(TTM) 438.73 | ||
Enterprise Value to Revenue 480.94 | Enterprise Value to EBITDA -8.02 | Shares Outstanding 20.01M | Shares Floating 11.30M |
Shares Outstanding 20.01M | Shares Floating 11.30M | ||
Percent Insiders 6.98 | Percent Institutions 100.38 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
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