Home 
Today's Top Picks 
Top Performers 
Watchlist 
My Robo Portfolios 
ETF Zone 
How It Works 
News - Chart
- Upturn Summary
- Highlights
- Valuation
Upturn AI Summary - About
Spruce Biosciences, Inc. Common Stock(SPRB)
Advisory History & Simulated Performance *
*as per simulation (see disclosures)- ALL
- 1Y
- 1M
- 1W
- BUY Advisory
- SELL Advisory (Profit)
- SELL Advisory (Loss)
- Profit
- Loss
- PASS (Skip)
Stock price based on last close Advisory Performance History (Simulated)
Upturn Advisory & Investor View for SPRB
11/09/2026: SPRB (1-star) is currently NOT-A-BUY. Pass it for now.
Spruce Biosciences is a clinical-stage biotechnology company focused on developing therapies for rare endocrine conditions, notably congenital adrenal hyperplasia. The company's primary strength lies in its specialized focus on the CRF1 receptor antagonist pathway. Its main investment story revolves around the potential success of its lead candidate, tildacerfont, in providing a non-steroidal alternative for patients. However, investors face substantial risks, including a lack of commercial revenue, significant reliance on a single asset, and the typical binary outcomes of clinical trials. The stock may suit speculative growth investors, but it requires close monitoring of clinical milestones and cash management, as there is no dividend income.
How to Read the Upturn Advisory
The Upturn Star Rating and the current BUY, SELL, or PASS advisory are generated by Upturn’s AI advisory engine based on proprietary signal analysis, price behavior, advisory history, and historical signal performance.
Company fundamentals, valuation, risks, and news provide supporting context about the business.
Investor Fit
| Investor style | Fit | Why |
|---|---|---|
| Growth investor | Mixed fit | The company offers high-risk growth potential but remains speculative until a product is successfully commercialized. |
| Momentum investor | Mixed fit | Momentum is highly conditional on positive clinical data readouts or regulatory breakthroughs. |
| Value investor | Weak fit | As a loss-making clinical-stage company, it lacks the traditional earnings or cash flow metrics used in value investing. |
| Dividend investor | Weak fit | The company is in an intensive R&D phase and does not provide income through dividends. |
| Low-risk investor | Weak fit | The high volatility and binary nature of clinical outcomes make this unsuitable for low-risk investors. |
Risk Profile
| Risk factor | Level | Why it matters |
|---|---|---|
| Price volatility | High | The stock price is extremely sensitive to clinical trial outcomes and biotech sector sentiment. |
| Valuation risk | High | Market valuations for clinical-stage firms are highly speculative and often detached from fundamental metrics. |
| Competition risk (Endocrine therapeutics) | Medium / high | Established competitors with more resources pose a significant threat to market entry and adoption. |
| Business quality | Medium | The company is in an early stage with no revenue-generating commercial assets. |
| Dividend income | Low / none | Investors cannot expect income from dividends in the near to medium term. |
| Execution risk | High | The ability to successfully navigate clinical trials and obtain FDA approval is the primary hurdle for the business. |
Price Behavior
Steep Decline
The stock price has dropped sharply with strong downward pressure.
Highly Choppy
The stock has experienced frequent, large price swings that make its near-term movement less predictable.
Analysis of Past Performance
Type Stock | Historic Profit -72.36% | Avg. Invested days 26 | Today’s Advisory PASS |
Upturn Advisory Rating  | Upturn Advisory Performance  2.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 11/09/2026 |
Upturn Scorecard
Upturn Star Rating 
Company Fundamentals
Financial Health Rating
Growth Momentum Score
Ownership
Top 5 Institutional Investors
Unit Economics (Per $1K Revenue)
Economic Dimensions
Quantitative Style Profile
Style Classification
Quality Focused
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 133.79M USD | Price to earnings Ratio - | 1Y Target Price 148 |
Price to earnings Ratio - | 1Y Target Price 148 | ||
Volume (30-day avg) 78.2K shares | Beta 3.54 | 52 Weeks Range 38.06 - 127.90 | Updated Date 11/08/2026 |
52 Weeks Range 38.06 - 127.90 | Updated Date 11/08/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -39.12 |
How Company Makes Money
| Business area | What it includes | Retail investor read |
|---|---|---|
| Clinical Development | Researching and developing tildacerfont to treat congenital adrenal hyperplasia. | The company currently spends money to develop medicine and does not earn revenue, making its success tied entirely to future clinical outcomes. |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 44.89M | Price to Sales(TTM) 3.78 |
Enterprise Value 44.89M | Price to Sales(TTM) 3.78 | ||
Enterprise Value to Revenue 77.32 | Enterprise Value to EBITDA -0.23 | Shares Outstanding 2.87M | Shares Floating 2.02M |
Shares Outstanding 2.87M | Shares Floating 2.02M | ||
Percent Insiders 3.37 | Percent Institutions 76.73 |
Financial Metrics
🧭 Investment Snapshot
Total Revenue (Scale)
Total money earned from selling products or services before any costs. It is needed to understand the scale of the business and its ability to generate income.
Net Income (Profit)
Final profit after all expenses, interest, and taxes are deducted. It is needed to determine the overall profitability available to shareholders.
Free Cash Flow (Cash Strength)
Cash remaining after operating activities and capital expenditures, showing cash available for growth. It is needed to evaluate the company’s ability to invest, pay dividends, or reduce debt.
📈 Growth & Strength
Operating Income (Core Profit)
Profit from core operations after deducting all operating expenses. It is needed to measure how efficiently the company runs its primary business activities.
EBITDA (Cash Earnings)
Earnings before interest, taxes, depreciation, and amortization, indicating operating cash potential. It is needed to compare operating performance across companies without accounting or financing differences.
Gross Profit (Unit Profitability)
Revenue minus cost of revenue, showing profit after direct production costs. It is needed to evaluate core business profitability before overhead expenses.
🛡️ Financial Safety
Cash (Liquidity Buffer)
Total cash and cash equivalents on hand. It is needed to evaluate immediate liquidity and financial flexibility.
Total Debt (Leverage Risk)
Total debt including both short-term and long-term components. It is needed to assess the company’s leverage and financial risk.
Net Working Capital (Short-Term Health)
Current assets minus current liabilities, indicating short-term liquidity strength. It is needed to assess whether the company can meet its short-term obligations.
🧱 Balance Sheet Strength
Stockholder Equity (Net Worth)
Total equity value held by shareholders. It is needed to understand the net worth of the company from the owners’ perspective.
Total Assets (Asset Base)
The full value of everything the company owns, including cash, inventory, equipment, and investments. It is needed to understand the resource base used to generate revenue.
Income Before Tax (Pre-Tax Earnings)
Income before provision for income taxes. It is needed to analyze profitability independent of tax structures.
⚙️ Cost & Drag Factors
Cost of Revenue (Production Cost)
Direct costs required to produce and deliver the products or services sold. It is needed to assess efficiency in production and service delivery.
Total Operating Expenses (Operating Cost)
Indirect costs of running the business such as salaries, marketing, and administration. It is needed to understand how much it costs to sustain ongoing business operations.
Income Tax Expense (Tax Drag)
Amount of taxes paid or payable to the government. It is needed to evaluate the impact of taxation on overall profitability.
Note: This website is maintained by Upturn Corporation, which is an investment adviser registered with the U.S. Securities and Exchange Commission. Such registration does not imply a certain level of skill or training. Investing in securities has risks. Past performance is no guarantee of future returns. No assurance is provided as to any particular investment return, and you may lose money using our services. You are strongly advised to consult appropriate counsel before making any investments in companies you learn about through our services. You should obtain appropriate legal, tax, investment, accounting, and other advice that takes into account your investment portfolio and overall financial situation. You are solely responsible for conducting due diligence on a potential investment. We do not affect trades for you. You will select your own broker through which to transact. Investments are not FDIC insured, they are not guaranteed, and they may lose value. Please see the Privacy Policy, Terms of Use, and Disclosure for more information.
All company names, trademarks, logos, and brands are the property of their respective owners and are used for identification and informational purposes only. Use of these names, trademarks, and logos does not imply endorsement by their respective owners.