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THAR
Upturn stock ratingUpturn stock rating

Tharimmune Inc. (THAR)

Upturn stock ratingUpturn stock rating
$1.8
Last Close (24-hour delay)
upturn advisory
PASS
  • BUY Advisory
  • SELL Advisory (Profit)​
  • SELL Advisory (Loss)​
  • Profit
  • Loss
  • Pass (Skip investing)
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
  • YEAR
  • MONTH
  • WEEK

Upturn Advisory Summary

06/27/2025: THAR (1-star) is currently NOT-A-BUY. Pass it for now.

Upturn Star Rating

rating

Not Recommended Performance

These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.

Number of Analysts

rating

1 Analysts rated it

Very few follow this stock; limited insights, higher-risk early investing.

1 Year Target Price $5

1 Year Target Price $5

Analysts Price Target For last 52 week
$5Target price
Low$0.95
Current$1.8
high$4.41

Analysis of Past Performance

Type Stock
Historic Profit -18.79%
Avg. Invested days 31
Today’s Advisory PASS
Upturn Star Rating Upturn stock ratingUpturn stock rating
Upturn Advisory Performance Upturn Advisory Performance 1.0
Stock Returns Performance Upturn Returns Performance 1.0
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 06/27/2025

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 7.59M USD
Price to earnings Ratio -
1Y Target Price 5
Price to earnings Ratio -
1Y Target Price 5
Volume (30-day avg) 1
Beta 1.06
52 Weeks Range 0.95 - 4.41
Updated Date 06/30/2025
52 Weeks Range 0.95 - 4.41
Updated Date 06/30/2025
Dividends yield (FY) -
Basic EPS (TTM) -7.85

Earnings Date

Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -
Operating Margin (TTM) -

Management Effectiveness

Return on Assets (TTM) -149.7%
Return on Equity (TTM) -400.44%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 6787796
Price to Sales(TTM) -
Enterprise Value 6787796
Price to Sales(TTM) -
Enterprise Value to Revenue -
Enterprise Value to EBITDA -6.32
Shares Outstanding 4212080
Shares Floating 2334123
Shares Outstanding 4212080
Shares Floating 2334123
Percent Insiders 39.8
Percent Institutions 2.56

Analyst Ratings

Rating 1
Target Price 5
Buy -
Strong Buy 1
Buy -
Strong Buy 1
Hold -
Sell -
Strong Sell -
Strong Sell -

ai summary icon Upturn AI SWOT

Tharimmune Inc.

stock logo

Company Overview

overview logo History and Background

Tharimmune, Inc. (formerly known as Advaxis, Inc.) is a clinical-stage biotechnology company focusing on developing novel therapies for inflammation and immunology. Advaxis focused on cancer treatments. The name change and strategic shift to immunology occurred in 2024, marking a significant change in direction.

business area logo Core Business Areas

  • Inflammation and Immunology: Develops therapies targeting the innate immune system to treat inflammatory and immunological diseases. Its lead product, TH104, is under development for treating steroid-resistant Graft-versus-Host Disease (srGvHD).

leadership logo Leadership and Structure

Dr. Alan Fuhrman is the current CEO. The company is structured around research and development, clinical operations, and business development.

Top Products and Market Share

overview logo Key Offerings

  • TH104: A modified synthetic molecule intended to modulate innate immunity and reduce inflammation. It is currently in clinical development for steroid-resistant Graft-versus-Host Disease (srGvHD). Market share data unavailable as the product is still in development. Competitors in the srGvHD space include Kadmon (acquired by Sanofi), Incyte (Jakafi), and several emerging therapies.

Market Dynamics

industry overview logo Industry Overview

The inflammation and immunology market is substantial and growing, driven by the increasing prevalence of autoimmune diseases, inflammatory conditions, and the need for novel therapies with improved efficacy and safety profiles.

Positioning

Tharimmune is positioned as a developer of novel therapies targeting the innate immune system, differentiating itself through its unique mechanism of action.

Total Addressable Market (TAM)

The TAM for inflammation and immunology therapies is estimated to be in the tens of billions of dollars annually. Tharimmune is targeting specific subsegments such as srGvHD, giving it a smaller but still significant potential market. Actual TAM target is srGvHD which is expected to reach ~$500M by 2030

Upturn SWOT Analysis

Strengths

  • Novel therapeutic approach targeting innate immunity
  • Potential to address unmet needs in inflammatory and immunological diseases
  • Experienced leadership team
  • Focus on srGvHD a serious disease

Weaknesses

  • Clinical-stage company with no approved products
  • Limited financial resources
  • High risk of clinical trial failure
  • Dependence on TH104

Opportunities

  • Successful clinical trials could lead to regulatory approval and commercialization
  • Partnerships with larger pharmaceutical companies
  • Expansion into other inflammatory and immunological indications
  • Fast Track approval by FDA

Threats

  • Competition from established pharmaceutical companies
  • Regulatory hurdles
  • Patent challenges
  • Adverse events in clinical trials

Competitors and Market Share

competitor logo Key Competitors

  • SNY
  • INCY
  • MRTX
  • BMY

Competitive Landscape

Tharimmune faces significant competition from larger, established pharmaceutical companies with greater resources and approved products. Its competitive advantage lies in its novel therapeutic approach.

Growth Trajectory and Initiatives

Historical Growth: Formerly Advaxis, the company's historical growth is not relevant to its current focus.

Future Projections: Future growth depends on the success of clinical trials for TH104.

Recent Initiatives: Name change to Tharimmune and strategic pivot to immunology.

Summary

Tharimmune is a high-risk, high-reward clinical-stage company with a novel approach to treating inflammatory and immunological diseases. Its success hinges on the clinical development of TH104. The company faces intense competition and regulatory hurdles. However, successful trials could lead to significant shareholder value. They have minimal product revenue and rely on investor confidence.

Peer Comparison

Sources and Disclaimers

Data Sources:

  • Company website
  • SEC filings
  • Analyst reports
  • Industry publications

Disclaimers:

This analysis is for informational purposes only and should not be considered investment advice. Investment in biotech companies is highly speculative and involves significant risk.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.

About Tharimmune Inc.

Exchange NASDAQ
Headquaters Bridgewater, NJ, United States
IPO Launch date 2022-01-12
CEO & Director Mr. Sireesh Appajosyula Pharm.D.
Sector Healthcare
Industry Biotechnology
Full time employees 2
Full time employees 2

Tharimmune, Inc., a clinical-stage biotechnology company, engages in the development of therapeutic candidates for rare, inflammatory, and oncologic conditions with high unmet need in the United States. The company's pre-clinical immuno-oncology pipeline includes TH104, a product candidate for the treatment of liver-related and other pruritogenic inflammatory conditions; TH023 which is phase 1 clinical trial used to treat multiple high value autoimmune indications; and HS1940, which targets programmed cell death protein 1 (PD-1). It has a research collaboration and product license agreement with Minotaur Therapeutics, Inc. for the development of proprietary targeted biologics. The company was formerly known as Hillstream BioPharma, Inc. and changed its name to Tharimmune, Inc. in September 2023. Tharimmune, Inc. was incorporated in 2017 and is headquartered in Bridgewater, New Jersey.