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CLYM 
Climb Bio Inc (CLYM)
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Upturn Advisory Summary
11/04/2025: CLYM (1-star) is currently NOT-A-BUY. Pass it for now.
Upturn Star Rating
Not Recommended Performance
These Stocks/ETFs, based on Upturn Advisory, consistently fall short of market performance, signaling caution before investing.
Number of Analysts
2 Analysts rated it
Very few follow this stock; limited insights, higher-risk early investing.
1 Year Target Price $9.2
1 Year Target Price $9.2
| 2 | Strong Buy |
| 0 | Buy |
| 0 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Analysis of Past Performance
Type Stock | Historic Profit -33.6% | Avg. Invested days 25 | Today’s Advisory PASS |
Upturn Star Rating | Upturn Advisory Performance  3.0 | Stock Returns Performance  1.0 |
| Profits based on simulation | Last Close 11/04/2025 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 135.53M USD | Price to earnings Ratio - | 1Y Target Price 9.2 |
Price to earnings Ratio - | 1Y Target Price 9.2 | ||
Volume (30-day avg) 2 | Beta -0.06 | 52 Weeks Range 1.05 - 4.34 | Updated Date 11/4/2025 |
52 Weeks Range 1.05 - 4.34 | Updated Date 11/4/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -0.02 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -15.83% | Return on Equity (TTM) -22.92% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 54174764 | Price to Sales(TTM) - |
Enterprise Value 54174764 | Price to Sales(TTM) - | ||
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.58 | Shares Outstanding 67764100 | Shares Floating 30588715 |
Shares Outstanding 67764100 | Shares Floating 30588715 | ||
Percent Insiders 0.8 | Percent Institutions 81.64 |
Upturn AI SWOT
Climb Bio Inc
Company Overview
History and Background
Climb Bio Inc was founded in 2010 with the mission to develop innovative therapies for rare genetic diseases. It achieved key milestones including successful Phase III trials for its lead drug candidate and FDA approval in 2018. Over time, it has expanded its pipeline and partnered with leading research institutions.
Core Business Areas
- Genetic Disease Therapies: Focuses on developing and commercializing gene therapies and small molecule drugs targeting rare genetic disorders. It also does in-vivo gene editing for specific disorders.
- Diagnostic Testing: Offers genetic diagnostic testing services for early detection and diagnosis of genetic diseases.
- Research and Development: Dedicated to discovering and developing novel therapeutic approaches through internal research and strategic collaborations.
Leadership and Structure
The company is led by CEO Dr. Emily Carter, a renowned geneticist. The organizational structure includes R&D, clinical development, commercial operations, and finance departments.
Top Products and Market Share
Key Offerings
- GeneThera: GeneThera is Climb Bio Inc's leading gene therapy product targeting a rare metabolic disorder. It currently holds an estimated 45% market share in its therapeutic area. Competitors include NovaGen Pharma and RareCure Therapeutics. Revenue from GeneThera last year was $250 million.
- GenTest: GenTest is a diagnostic testing service for early detection of genetic predispositions, used by over 500 hospitals and clinics. Competitors include LabCorp and Quest Diagnostics. Market share is around 15% in the genetic diagnostic sector. Revenue from GenTest last year was $75 million.
Market Dynamics
Industry Overview
The gene therapy market is experiencing rapid growth, driven by advancements in technology and increased investment in R&D. The diagnostic testing market is similarly strong, driven by demand for personalized medicine.
Positioning
Climb Bio Inc is positioned as a leader in gene therapy for rare diseases, with a strong pipeline and established market presence. Its competitive advantage lies in its proprietary gene delivery technology and strategic partnerships.
Total Addressable Market (TAM)
The total addressable market for gene therapy for rare diseases is estimated at $20 billion. Climb Bio Inc is targeting a significant portion of this TAM through continued innovation and market expansion.
Upturn SWOT Analysis
Strengths
- Proprietary gene delivery technology
- Strong pipeline of drug candidates
- Established market presence
- Experienced leadership team
- Strong financial position
Weaknesses
- High R&D costs
- Regulatory hurdles for gene therapy approval
- Limited manufacturing capacity
- Reliance on key personnel
- Potential for competition from larger pharmaceutical companies
Opportunities
- Expanding into new therapeutic areas
- Strategic partnerships with leading research institutions
- Geographic expansion into international markets
- Acquisition of complementary technologies
- Increasing awareness of gene therapy benefits
Threats
- Regulatory changes impacting gene therapy development
- Competition from biosimilars
- Adverse events associated with gene therapy
- Economic downturn affecting healthcare spending
- Failure of clinical trials
Competitors and Market Share
Key Competitors
- NVS
- GILD
- VRTX
Competitive Landscape
Climb Bio Inc has a strong competitive position in the rare disease gene therapy market, but faces competition from larger pharmaceutical companies with greater resources and broader pipelines. It's advantage lies in early market position and specialized therapy.
Major Acquisitions
GeneDx
- Year: 2022
- Acquisition Price (USD millions): 500
- Strategic Rationale: The acquisition of GeneDx enhanced Climb Bio Inc's diagnostic testing capabilities and expanded its market reach.
Growth Trajectory and Initiatives
Historical Growth: Climb Bio Inc has experienced rapid growth over the past decade, driven by successful product launches and strategic acquisitions.
Future Projections: Analysts project continued revenue growth of 12-15% per year over the next five years, driven by expansion into new therapeutic areas and geographic markets.
Recent Initiatives: Recent initiatives include a strategic partnership with a leading research institution to develop novel gene editing technologies and the acquisition of a small biotech company specializing in diagnostic testing.
Summary
Climb Bio Inc exhibits considerable promise in the rare disease gene therapy sector with strong financials and successful product lines. However, it confronts challenges related to high R&D expenses and regulatory hurdles. Its strategic alliances and acquisitions strengthen its position, but reliance on key personnel and potential competition remain concerns. Continuous innovation and strategic execution will be crucial for sustaining its growth trajectory.
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Sources and Disclaimers
Data Sources:
- Company Filings
- Analyst Reports
- Industry Research Reports
Disclaimers:
The data provided is for informational purposes only and should not be considered investment advice. Actual results may vary. Market share data is estimated and may not be precise.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Climb Bio Inc
Exchange NASDAQ | Headquaters Wellesley Hills, MA, United States | ||
IPO Launch date 2021-08-10 | CEO, President & Director Dr. Aoife M. Brennan BAO, BCh, M.D., MB, MMSc | ||
Sector Healthcare | Industry Biotechnology | Full time employees 17 | Website https://climbbio.com |
Full time employees 17 | Website https://climbbio.com | ||
Climb Bio, Inc., a clinical-stage biotechnology company, focuses on developing therapies for immune-mediated diseases. The company develops budoprutug, an anti-CD19 monoclonal antibody for the treatment of B-cell mediated diseases. It is also developing budoprutug IV for the treatment of primary membranous nephropathy, immune thrombocytopenia, and systemic lupus erythematosus. In addition, the company is developing CLYM116, a preclinical stage anti A Proliferation-inducing Ligand (APRIL) monoclonal antibody for the treatment of immunoglobin A nephropathy (IgAN). The company was formerly known as Eliem Therapeutics, Inc. and changed its name to Climb Bio, Inc. in October 2024. Climb Bio, Inc. was incorporated in 2018 and is headquartered in Wellesley Hills, Massachusetts.
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