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Janux Therapeutics Inc (JANX)

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Upturn Advisory Summary
02/20/2026: JANX (1-star) is currently NOT-A-BUY. Pass it for now.
1 Year Target Price $63.71
1 Year Target Price $63.71
| 11 | Strong Buy |
| 1 | Buy |
| 1 | Hold |
| 0 | Sell |
| 0 | Strong Sell |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 807.18M USD | Price to earnings Ratio - | 1Y Target Price 63.71 |
Price to earnings Ratio - | 1Y Target Price 63.71 | ||
Volume (30-day avg) 13 | Beta 2.87 | 52 Weeks Range 12.12 - 36.25 | Updated Date 02/20/2026 |
52 Weeks Range 12.12 - 36.25 | Updated Date 02/20/2026 | ||
Dividends yield (FY) - | Basic EPS (TTM) -1.67 |
Earnings Date
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -352.51% |
Management Effectiveness
Return on Assets (TTM) -10.49% | Return on Equity (TTM) -12.48% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value -157946474 | Price to Sales(TTM) 80.72 |
Enterprise Value -157946474 | Price to Sales(TTM) 80.72 | ||
Enterprise Value to Revenue 972.59 | Enterprise Value to EBITDA -33.8 | Shares Outstanding 60147807 | Shares Floating 40996745 |
Shares Outstanding 60147807 | Shares Floating 40996745 | ||
Percent Insiders 7 | Percent Institutions 107.75 |
Upturn AI SWOT
Janux Therapeutics Inc

Company Overview
History and Background
Janux Therapeutics Inc. was founded in 2017 with a focus on developing innovative cancer therapies. The company's evolution has been driven by its proprietary tumor-targeted protein degrader platform, aiming to create next-generation therapeutics for difficult-to-treat cancers. Key milestones include the initiation of clinical trials and strategic collaborations.
Core Business Areas
- Tumor-Targeted Protein Degraders: Janux Therapeutics develops novel protein degraders designed to specifically target cancer cells, leading to their destruction. This platform aims to address limitations of current therapies by offering greater precision and efficacy.
Leadership and Structure
Janux Therapeutics is led by a team of experienced professionals in drug development, oncology, and business management. The organizational structure is typical of a biotechnology company, with research and development as a primary focus, supported by clinical operations, regulatory affairs, and corporate functions.
Top Products and Market Share
Key Offerings
- Description: JANX001 is a novel tumor-targeted protein degrader currently in clinical development for various solid tumors. Specific market share data is not yet available due to its early-stage development. Competitors in the broader oncology drug market are numerous and include companies developing targeted therapies, immunotherapies, and chemotherapies. For protein degraders, competitors include companies like Arvinas and Kymera Therapeutics.
- Product Name 1: JANX001
Market Dynamics
Industry Overview
The oncology therapeutics market is a rapidly growing and highly competitive sector driven by significant unmet medical needs and advancements in scientific understanding of cancer biology. The development of targeted therapies and novel modalities like protein degraders represents a key trend.
Positioning
Janux Therapeutics is positioned as an innovator in the emerging field of tumor-targeted protein degraders. Its proprietary platform offers a potential competitive advantage by enabling the development of highly specific and potent anti-cancer agents. However, as a clinical-stage company, it faces the inherent risks associated with drug development and faces intense competition from established pharmaceutical companies and other emerging biotech firms.
Total Addressable Market (TAM)
The total addressable market for oncology drugs is in the hundreds of billions of dollars globally. Janux Therapeutics, by focusing on specific cancer types and leveraging its unique platform, aims to capture a significant portion of the TAM for its therapeutic candidates as they advance through development and gain regulatory approval.
Upturn SWOT Analysis
Strengths
- Proprietary tumor-targeted protein degrader platform
- Experienced leadership team
- Focus on addressing unmet needs in oncology
- Potential for differentiated therapeutic approach
Weaknesses
- Clinical-stage company with no approved products
- Significant funding requirements for clinical development
- Reliance on the success of a single platform technology
- Early stage of product pipeline
Opportunities
- Advancements in precision medicine
- Increasing investment in oncology research and development
- Potential for strategic partnerships and collaborations
- Expansion into new indications and cancer types
Threats
- Clinical trial failures or delays
- Regulatory hurdles and approval processes
- Intense competition from established and emerging companies
- Pricing pressures and market access challenges
- Intellectual property challenges
Competitors and Market Share
Key Competitors
- Arvinas Inc. (ARVN)
- Kymera Therapeutics Inc. (KYMR)
- Nurix Therapeutics Inc. (NRIX)
Competitive Landscape
Janux Therapeutics' advantages lie in its specific tumor-targeting approach within the protein degrader space. However, it faces competition from companies with more advanced pipelines, established clinical data, and greater financial resources. The competitive landscape is characterized by rapid innovation and the high risk associated with drug development.
Growth Trajectory and Initiatives
Historical Growth: Janux Therapeutics' growth trajectory has been focused on scientific advancement, platform development, and progress through preclinical and early-stage clinical development. Growth is measured by pipeline progression and the acquisition of R&D capabilities.
Future Projections: Future growth projections for Janux Therapeutics are contingent on the successful outcomes of its clinical trials, regulatory approvals, and potential commercialization of its drug candidates. Analyst estimates would typically focus on the potential market size and success probability of their pipeline assets.
Recent Initiatives: Recent initiatives likely include advancing JANX001 into later-stage clinical trials, exploring new applications for its protein degrader platform, and potentially seeking strategic partnerships or financing rounds to fund ongoing development.
Summary
Janux Therapeutics is a clinical-stage biotechnology company with a promising proprietary platform for developing tumor-targeted protein degraders. Its strengths lie in its innovative technology and experienced team, while its main weaknesses are its early stage of development and reliance on clinical success. Opportunities exist in the expanding oncology market and advancements in precision medicine, but threats include clinical trial failures and intense competition. The company needs to focus on achieving key clinical milestones and securing adequate funding to navigate the challenging drug development landscape.
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Sources and Disclaimers
Data Sources:
- Company filings (SEC)
- Financial news outlets
- Biotechnology industry reports
- Market research databases
Disclaimers:
This analysis is based on publicly available information and is for informational purposes only. It does not constitute investment advice. Investing in biotechnology stocks, especially clinical-stage companies, carries significant risk. Investors should conduct their own due diligence and consult with a qualified financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Janux Therapeutics Inc
Exchange NASDAQ | Headquaters San Diego, CA, United States | ||
IPO Launch date 2021-06-11 | President, CEO & Director Dr. David Alan Campbell Ph.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 109 | Website https://www.januxrx.com |
Full time employees 109 | Website https://www.januxrx.com | ||
Janux Therapeutics, Inc., a clinical stage biopharmaceutical company, develops immunotherapies based on Tumor Activated T Cell Engager (TRACTr) and Tumor Activated Immunomodulator (TRACIr) platforms technology to treat patients with cancer. Its clinical candidates include JANX007, a prostate-specific membrane antigen or PSMA-TRACTr, which is in Phase 1 clinical trial in adults for the treatment of metastatic castration-resistant prostate cancer and the vasculature of other tumors; and JANX008, an epidermal growth factor receptor that is in Phase 1 clinical trial for the treatment of various solid cancers, including colorectal cancer, squamous cell carcinoma of the head and neck, non-small cell lung cancer, renal cell carcinoma, small cell lung cancer, pancreatic ductal adenocarcinoma, and triple-negative breast cancer. Janux Therapeutics, Inc. has strategic research collaboration agreement with Merck Sharp & Dohme Corp. to develop TRACTr product candidates. The company was incorporated in 2017 and is headquartered in San Diego, California.

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